Null mice show increased levels of S-nitrosated proteins, increased beta adrenergic receptor numbers in lung and heart, diminished tachyphylaxis to ?2-adrenergic receptor agonists, hyporesponsiveness to methacholine and allergen challenge and reduced infarct size after occlusion of the coronary artery.
12.
It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies, but its high potency and long duration of action causes D 1 receptor downregulation and tachyphylaxis, and unlike other D 1 full agonists such as SKF-82, 958, it does not produce place preference in animals.
13.
Ro4-1539 has never formally undergone clinical trials in humans, but based on its effects in animals it would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching, tachyphylaxis and respiratory depression, which could be harmful or fatal.
14.
It has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, dependence would be expected to develop rapidly based on the potency of the drug, as it is of a similar strength to the potent fentanyl analogues and so would most likely cause pronounced tachyphylaxis following repeated dosing.
15.
As for the cat turning into a, um, pussy, I would imagine ( but I don't know for a fact ) that there could be tachyphylaxis of the receptors for cortisol, norepinephrine, etc . And the body is full of all kinds of feedback systems; see for example cortisol # Regulation, so the initial rage could have led later to a turning down of the systems that mediated the rage . ( Or maybe, the cat was just very tired . )-- talk ) 19 : 28, 5 November 2015 ( UTC)
