| 11. | The therapeutic index also factors whether a drug can be used as a time release drug.
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| 12. | With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in the clinic in 1946.
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| 13. | A low therapeutic index indicates that there is a high risk of toxicity when using the drug.
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| 14. | For instance most formularies will not cover barbiturates since their therapeutic index is low compared to benzodiazepines.
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| 15. | Methocarbamol has a high therapeutic index, i . e ., a wide range of safe and effective dosages.
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| 16. | Medication is said to have a narrow or wide " therapeutic index " or " therapeutic window ".
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| 17. | Nevertheless, the therapeutic index can be viewed as an upper bound to the protective index for a given substance.
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| 18. | They have a high therapeutic index, that is, phage therapy would be expected to give rise to few strain.
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| 19. | For some hepatically metabolized drugs with very low therapeutic indexes, co-administration with methimazole may not be possible at all.
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| 20. | Therapeutic index also does not take into account the ease or difficulty of reaching a toxic or lethal dose.
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