While levels of toxins are generally lower in the West than in most polluted parts of Eastern Europe, Perera doubts that there is a threshold concentration below which air pollution does not harm fetuses.
12.
Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium.
13.
CSP is produced by proteolytic cleavage of a 41-amino acid precursor peptide ( ComC ); is secreted by an ABC transporter ( ComAB ); and is detected by a sensor kinase protein ( ComD ) once it has reached a threshold concentration.
14.
However, the threshold concentration of allopregnanolone to inhibit L-VGCCs was determined to be 3 ?M ( 3, 000 nM ), which is far greater than the concentration of 5 nM that has been estimated to be naturally produced in the human brain.
