So many thymocytes ( T cells ) die during the maturation process because there is intensive screening to make sure each thymocyte has the ability to recognize self tolerance.
12.
The human homolog was isolated in 1980 as a 25kDa protein ( p25 ) of T-lymphoblastoid cell line MOLT-3 binding with anti-monkey-thymocyte antisera.
13.
It was originally named theta ( ? ) antigen, then Thy-1 ( "'THYmocyte differentiation antigen 1 "') due to its prior identification in thymocytes ( precursors of T cells in the thymus ).
14.
Repeated daily administration of the peptide by subcutaneous injection ( 10 �g / kg / day ) for 2 weeks to rats does not cause any changes in blood counts, blood chemistry or in the proportion of thymocyte or lymphocyte subsets.
15.
Since then, he had tried to demonstrate that thymocyte-thymocyte ( or, T cell-T cell, so called T-T ) interaction is really present and T cells can be developed by the interaction in vivo.
16.
Since then, he had tried to demonstrate that thymocyte-thymocyte ( or, T cell-T cell, so called T-T ) interaction is really present and T cells can be developed by the interaction in vivo.
17.
The most primitive cells in the thymus are the early thymocyte progenitors ( ETP ), which retain all lymphoid and myeloid potential but exist only transiently, rapidly differentiating into T and NK lineages . ( Medical Immunology, p . 118)
18.
It is less commonly used than the similar anti-thymocyte globulin ( ATG ), and like ATG it is associated with cytokine release syndrome in the short term and an increased risk of post-transplant lymphoproliferative disorder in the long term.
19.
In the trial, severe immunosuppression with high doses of cyclophosphamide and anti-thymocyte globulin is used with the aim of " turning off " the immunologic system ", and then autologous hematopoietic stem cells are reinfused to regenerate a new one.
20.
Anti-thymocyte globulin ( ATG ), an immunosuppressive agent that selectively destroys T lymphocytes is being studied for use in CIDP . Anti-thymocyte globulin is the gamma globulin fraction of antiserum from animals that have been immunized against human thymocytes.
