| 11. | This evidence is supportive of the notion that tropomyosin isoforms are subject to temporal regulation.
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| 12. | Upon the washing out of cytochalasin D, tropomyosin isoform sorting was re-established.
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| 13. | The protein tropomyosin covers the myosin binding sites of the actin molecules in the muscle cell.
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| 14. | Niacin appears to upregulate BDNF and tropomyosin receptor kinase B ( TrkB ) expression as well.
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| 15. | The mechanisms that underlie tropomyosin isoform sorting appear to be inherently flexible and dynamic in nature.
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| 16. | The action potential releases calcium ions that free up the tropomyosin and allow the muscle to contract.
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| 17. | Studies suggest that tropomyosin isoform sorting may also be influenced by the actin isoform composition of microfilaments.
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| 18. | The thin filament of smooth muscle is made of actin, tropomyosin, caldesmon, and calmodulin.
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| 19. | Furthermore, studies have highlighted a link between tropomyosin isoform expression and the acquisition of metastatic properties.
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| 20. | A vast array of tropomyosin isoforms are generated by using a combination of different genes and alternative splicing.
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