By 1922, Suramin was generally combined with tryparsamide ( another pentavalent organoarsenic drug ), the first drug to enter the nervous system and be useful in the treatment of the second stage of the gambiense form.
12.
The trio of physicians at Wisconsin went on to publish more than 100 papers on neurosyphilis; in particular, they developed and refined an alternative to Wagner-Jauregg therapy, using an arsenical medication called tryparsamide.
13.
The Rockefeller Institute sent Louise Pearce to L & eacute; opoldville in the Belgian Congo in 1920 to test tryparsamide, " trusting her vigorous personality to carry out an assignment none too easy for a woman physician and not without its dangers ".
14.
Although it was generally much less powerful against spirochetes than against trypanosomes, tryparsamide's ability to pass the blood-brain barrier and enter the central nervous system made it a useful treatment for syphilis of the brain and spinal cord and the chronic form, general paresis.
