What was different about Brennan's research was that rats were treated with zymosan because it stimulates a particular immune system cell called a macrophage.
12.
And his findings : That by injecting them with a drug called zymosan, he could reduce blood cholesterol-- whether induced by stress or diet.
13.
When an agent, zymosan, was injected into the tunicate " Styela plicata " ( causing inflammation ), secretion of this collectin was tripled within 96 hours.
14.
One group received zymosan prior to being stressed, another received an injection of a compound with no effect on macrophage prior to being stressed, another received zymosan without being stressed, and one group received saline, with no stress.
15.
One group received zymosan prior to being stressed, another received an injection of a compound with no effect on macrophage prior to being stressed, another received zymosan without being stressed, and one group received saline, with no stress.
16.
In addition, a role for paracaspase has been shown in the innate immune response mediated by the zymosan receptor Dectin-1 in macrophages and dendritic cells, and in response to the stimulation of certain G protein-coupled receptors.
17.
Intraperitoneal administration of C15 ( 0.32 ng / kg ) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil ( 63 % ) and monocyte ( 62 % ) recruitment with a concomitant reduction in proinflammatory mediator expression.
18.
Intraperitoneal administration of C15 ( 0.32 ng / kg ) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil ( 63 % ) and monocyte ( 62 % ) recruitment with a concomitant reduction in proinflammatory mediator expression.
