| 21. | Aldosterone plays an important role in the long-term regulation of blood pressure.
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| 22. | Increased aldosterone levels results in salt and water absorption in the distal collecting tubule.
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| 23. | If aldosterone is deficient, maintenance therapy also includes oral doses of fludrocortisone acetate.
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| 24. | Aldosterone is part of the renin angiotensin system.
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| 25. | A high aldosterone-to-renin ratio suggests the presence of primary hyperaldosteronism.
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| 26. | The activity of ENaC in colon and kidney is modulated by the mineralcorticoid aldosterone.
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| 27. | Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone.
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| 28. | The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and other steroids.
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| 29. | Aldosterone synthase normally is not ACTH sensitive, and only activated by angiotensin II.
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| 30. | In both primary and secondary hyperaldosteronism, concentrations of the hormone aldosterone are elevated.
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