"' Fenisorex "'( amphetamine-like anorectic drug which does not appear to have ever been marketed.
22.
CART is an anorectic peptide and is widely expressed in both the central and peripheral nervous systems, particularly concentrated in the hypothalamus.
23.
In animal studies it has anxiolytic, antidepressant and anorectic effects, and it has successfully passed Phase I clinical trials in humans.
24.
It was found that both central and peripheral injection of Sct reduce food intake in mouse, indicating an anorectic role of the peptide.
25.
This side effect led to the withdrawal of fenfluramine as an anorectic drug worldwide, and later to the withdrawal of benfluorex in Europe.
26.
"' Acridorex "'( amphetamine which was investigated as an anorectic but does not appear to have ever been marketed.
27.
"' Flucetorex "'( amphetamine which was investigated as an anorectic but does not appear to have ever been marketed.
28.
Why would some Anorectic Stimulants cause Gastric symptoms ( Such as Constipation \ Diarrhea ) to some people ? what are the proposed mechanisms?
29.
It has potent anorectic effects and has encouraged the development of selective 5-HT 2C receptor agonists for the treatment of obesity as well.
30.
In animal studies it has been shown to produce both anxiolytic and antidepressant effects, and also reduces food consumption suggesting a possible anorectic effect.
