A fairly recent article that talks about ADCC is Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer .-- JWSchmidt 22 : 54, 8 December 2006 ( UTC)
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Since 1998, Patrick Baeuerle investigates the therapeutic potential of T cell-engaging BiTE antibodies for therapy of cancer, and has been responsible at Micromet for the development of blinatumomab and several other antibody therapies.
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Today, Mitch Sayare, chief executive of ImmunoGen, a Cambridge, Mass . company that specializes in monoclonal antibody treatments for cancer, said many of the 402 cancer treatments now in development are antibody therapies.
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MassBiologics, a non-profit organization engaged in the discovery, development and manufacturing of biologic therapies, is cooperating with researchers at NIH and the CDC developed a monoclonal antibody therapy that demonstrated efficacy in animal models.
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Another phase I clinical trial has reported a dose-dependent inhibition of IFN-? / ?-inducible genes in both peripheral blood and skin biopsies in SLE patients treated with anti-IFN monoclonal antibody therapy.
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Technologies developed in her laboratory and that of Dr . Andreas Herrmann at City of Hope are being used by a newly formed company, LA Cell, Inc ., which hopes to develop cell-penetrating antibody therapies.
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The antisense field anticipated that the approval of fomivirsen marked the beginning of a new age of antisense drug treatments, that would be similar to the uptake of monoclonal antibody therapy, but the next FDA approval of an antisense drug came in 2013.
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"' MDX-1097 "'( also called "'IST-1097 "') is a monoclonal antibody therapy being assessed in clinical trials as a treatment for multiple myeloma, a type of white blood cell cancer.
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Cell surface receptors are common targets for antibody therapies and include CD20, CD274 and CD279 . Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death.