This paved the way for the elaboration of a new generation of safer, codeine-based specific antitussive and antidiarrheal formulations.
23.
Drotebanol has powerful antitussive ( cough suppressant ) effects, and is around 10x more potent than codeine in producing this effect.
24.
In the early 1950s, methadone ( most times the racemic HCl salts mixture ) was also investigated for use as an antitussive.
25.
It also has antitussive effects, and reduces the rewarding and analgesic effects of morphine, although it did not prevent the development of dependence.
26.
It binds to the same receptors in the brain as noscapine to act as an antitussive, and has also been used in tissue culture media.
27.
It has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in some countries.
28.
Tannic acid is also used to produce tannate salts of certain antihistamine and antitussive products to impart increased stability or slow release properties to the active pharmaceutical ingredient.
29.
Thebacon is an opioid agonist narcotic analgesic of the middle range and a strong antitussive, primarily used in Europe, although it is no longer in common use.
30.
Thebacon's analgesic and antitussive potency is slightly higher than that of its parent compound hydrocodone, which gives it approximately eight times the milligramme strength of codeine.
