Renin, a proteolytic enzyme, cleaves angiotensinogen to angiotensin I, which is converted to angiotensin II . In the case of chronic aortic insufficiency with resultant cardiac remodeling, heart failure will develop, and it is possible to see systolic pressures diminish.
22.
The cause of death was " heart disease, aortic insufficiency, and probably myocarditis . " Edmund Kirby Smith, the last surviving full general of the Confederacy, served as the " chief mourner " as Beauregard was interred in the vault of the Army of Tennessee in historic Metairie Cemetery.
23.
Regurgitation in or near the heart is often caused by valvular insufficiency ( insufficient function, with incomplete closure, of the heart valves ); for example, aortic valve insufficiency causes regurgitation through that valve, called aortic regurgitation, and the terms " aortic insufficiency " and " aortic regurgitation " are so closely linked as usually to be treated as metonymically interchangeable.
