Through effects on cell signaling, inflammation, cell cycle, and protease production, apigenin has demonstrated effectiveness against a wide range of cancer types, while not showing toxicity to normal cells.
22.
Apigenin, a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent, has been found to regulate normal differentiation by suppressing involucrin, and this is associated with reduced cell proliferation without apoptosis.
23.
"' Apigenin "'( 42, 5, 7-trihydroxyflavone ), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides.
24.
The enzyme apigenin 4'- O-methyltransferase uses S-adenosyl methionine and 5, 7, 4'- trihydroxyflavone ( apigenin ) to produce S-adenosylhomocysteine and 4'- methoxy-5, 7-dihydroxyflavone ( acacetin ).
25.
The enzyme apigenin 4'- O-methyltransferase uses S-adenosyl methionine and 5, 7, 4'- trihydroxyflavone ( apigenin ) to produce S-adenosylhomocysteine and 4'- methoxy-5, 7-dihydroxyflavone ( acacetin ).
26.
Among the related, coloring matters are : chrysin from poplar buds, apigenin from parsley, luteolin from weld, mignonette and dyer's broom, fisetin from young fustic and yellow cypress, galangin from galangal root, and myricetin from " Nageia nagi ".
27.
"' Vitexin "'is an apigenin flavone glucoside, a chemical compound found in the passion flower, " Vitex agnus-castus " ( chaste tree or chasteberry ), in the " Phyllostachys nigra " bamboo leaves, in the pearl millet ( Pennisetum millet ), and in Hawthorn.
28.
As well, the plant contains oleanolic acid, 7-oxositosterol, 7-oxostigmasterol, 7alpha-hydroxy stigmasterol, stigmasterol, 5-hydroxy-7, 4'- dimethoxy flavone, pillion, gonzalitosin I, tricin, cosmosin, apigenin-7-O-beta-D-( 6-O-p-coumaryl ) glucopyranoside, anisofolin A and luteolin.
29.
A variety of flavonoids in " Scutellaria " species have been found to bind to the benzodiazepine site and / or a non-benzodiazepine site of the GABA A receptor, including baicalin, baicalein, wogonin, apigenin, oroxylin A, scutellarein, and skullcapflavone II . Baicalin and baicalein, wogonin, and apigenin have been confirmed to act as positive allosteric modulators and produce anxiolytic effects in animals, whereas oroxylin A acts as a negative allosteric modulator ( and also, notably, as a dopamine reuptake inhibitor ).
30.
A variety of flavonoids in " Scutellaria " species have been found to bind to the benzodiazepine site and / or a non-benzodiazepine site of the GABA A receptor, including baicalin, baicalein, wogonin, apigenin, oroxylin A, scutellarein, and skullcapflavone II . Baicalin and baicalein, wogonin, and apigenin have been confirmed to act as positive allosteric modulators and produce anxiolytic effects in animals, whereas oroxylin A acts as a negative allosteric modulator ( and also, notably, as a dopamine reuptake inhibitor ).
