A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes.
22.
Ro autoantigen protein ( white ) binds the end of a double-stranded Y RNA ( red ) and a single stranded RNA ( blue ) . ( PDB : 1YVP ) . ]]
23.
Specifically, " M . tuberculosis " blocks the bridging molecule, early endosomal autoantigen 1 ( EEA1 ); however, this blockade does not prevent fusion of vesicles filled with nutrients.
24.
The TYR gene encodes the protein tyrosinase, which is not a component of the immune system, but is an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a major autoantigen in generalized vitiligo.
25.
Citrullinated vimentin may be an autoantigen in RA and other autoimmune diseases, and is used to study RA . Moreover, antibodies against mutated citrullinated vimentin ( MCV ) may be useful for monitoring effects of RA therapy.
26.
In collaboration with genetic experts at UNC, Falk and his colleagues determined that ANCA autoantigen genes are activated or silenced through epigenetic control, that is, by factors that regulate gene expression without altering the underlying DNA sequence.
27.
Their central role in excitotoxicity and prevalence in the central nervous system has been linked or speculated to be linked to many neurodegenerative diseases, and several other conditions have been further linked to glutamate receptor gene mutations or receptor autoantigen / antibody activity.
28.
It has been found that La autoantigen ( La ) is required for Coxsackievirus B3 ( CVB3 ) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.
29.
In 2004, this same group of investigators proposed a new theory of autoimmunity, called the theory of autoantigen complementarity, based on the observation from human studies that patients reacted with complementary peptides to proteinase 3 as well as the initial sense peptide.
