TACN is one of the oligomers derived from aziridine, C 2 H 4 NH . Other members of the series include piperazine, C 4 H 8 ( NH ) 2, and the cyclic tetramer 1, 4, 7, 10-tetraazacyclododecane.
22.
The Wenker synthesis protocol using " trans "-2-aminocyclooctanol, available from reaction of ammonia with the epoxide of cyclooctene, gives a mixture of cyclooctenimine ( the Wenker aziridine product ) and cyclooctanone ( a competing Hofmann elimination product ).
