Only about 5 10 % of levodopa crosses the blood brain barrier, while the remaining is metabolized elsewhere in the body.
22.
On the other hand, absence of the glial scar has been associated with impairments in the repair of the blood brain barrier.
23.
It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins.
24.
Additionally, once the drug has entered the blood stream, L-DOPA utilizes the same pathways to cross the blood brain barrier as natural protein.
25.
While epoetin alpha is capable of crossing the blood brain barrier via active transport the amounts appearing in the CNS are very low.
26.
Moclobemide has good penetration across the blood brain barrier with peak plasma levels within the central nervous system occurring 2 hours after administration.
27.
Systemic injection of pilocarpine can compromise the blood brain barrier allowing pilocarpine to gain access to the brain which can lead to chronic epilepsy.
28.
The subarachnoid space is the location of the interface between the vascular tissue and the cerebrospinal fluid and is active in the blood brain barrier.
29.
Boockvar is the principal investigator of several clinical trials using blood brain barrier disruption to deliver high dose chemotherapy for patients with malignant brain tumors.
30.
As a result, the nervous system has a number of mechanisms designed to protect it from internal and external assaults, including the blood brain barrier.
