Blood vessel formation during embryogenesis consists of vasculogenesis, the formation of a primary capillary network followed by a second remodeling and restructuring into a finer tertiary network-studies utilizing ephrin-B2 deficient mice showed a disruption of the embryonic vasculature as a result of a deficiency in the restructuring of the primary network.
22.
"' Intravoxel incoherent motion "'( IVIM ) imaging is a concept and a method initially introduced and developed by Le Bihan et al . to quantitatively assess all the microscopic translational motions that could contribute to the signal acquired with diffusion MRI . In biological tissue, these motions essentially are molecular diffusion of water and microcirculation of blood in the capillary network ( perfusion ).
23.
Citing Chen and Gorski's research, Fish wrote that " several broadly expressed microRNAs regulate in vitro endothelial cell behavior, including proliferation, migration, and the ability to form capillary networks ", and sought to describe the " in vivo " functionality of a specific set of microRNAs and their targets; the group was able to isolate a particular microRNA ( miR-126 ) as the most highly enriched in endothelial cells.
