| 21. | CENP-A associates with the centromere and is necessary for assembly of the kinetochore.
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| 22. | Instead, they remain tightly associated with the centromeres of non-disjoined sister chromatids.
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| 23. | Anti-centromere and anti-p62 antibodies are also found in ( PBC ).
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| 24. | The inner centromere proteins ( INCENPs ),
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| 25. | Yeast, " Drosophila " and mammals all have heterochromatin flanking their centromeres.
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| 26. | Finally, an interesting recent discovery is having double-stranded RNA specify centromere location.
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| 27. | This allows the detection of antibodies to mitosis-specific antigens, such as centromere antibodies.
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| 28. | Thus, a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma.
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| 29. | Overexpression of CENPA and CENPH ( centromere protein H ) is also associated with colorectal cancer.
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| 30. | The homologous nature of the two viral centromeres would incite the grouping of both sets into tetrads.
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