Cyanocobalamin is usually converted to hydroxocobalamin in the serum, whereas hydroxocobalamin is converted to either methylcobalamin or 5-deoxyadenosyl cobalamin.
22.
This property allows the convenient preparation of cobalamin analogs with different substituents, via nucleophilic attack on alkyl halides and vinyl halides.
23.
The protein cubilin binds to intrinsic factor-cobalamin complex and is expressed in the distal small intestine and proximal renal tubule.
24.
Related areas of interest include the reactivity of metal-carbon bonds, e . g . in cobalamins and the pentacyanocobaltate derivatives.
25.
The mature enzyme is a homodimer with the N-terminal CoA binding domain and the C-terminal cobalamin-binding domain.
26.
Thus, acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin.
27.
The aerobic cobalt chelatase ( aerobic cobalamin biosynthesis pathway ) consists of three subunits, CobT, CobN ( ) and CobS ( ).
28.
A 2003 study found no significant difference in absorption for serum levels from oral versus sublingual delivery of 0.5 mg of cobalamin.
29.
In addition, vegetarians, are at risk for consuming a diet low in cobalamin as they voluntarily abstain from animal sources of B 12.
30.
CODH and ACS often occur together in a tetrameric complex, the CO being transported via a tunnel and the methyl group being provided by methyl cobalamin.
