The method by which flumazenil acts to prevent non-benzodiazepine tolerant overdose from causing potential harm is via preventing the benzodiazepines and Z-drugs from binding to the GABA A receptors via competitive inhibition which the flumazenil creates.
22.
Because of its structural similarity to plasminogen and tissue plasminogen activator, competitive inhibition leads to reduced fibrinolysis, and as a result of the stimulation of secretion of plasminogen activator inhibitor 1, Lp ( a ) leads to thrombogenesis.
23.
Pharmacologically, it decreases the sympathetic stimulation on cardiac muscle predominantly through partial depletion of catecholamine via competitive inhibition of reuptake by storage granule, which lead to further depletion due to spontaneous leakage as a result of disturbance of equilibrium.
24.
The biological mechanisms are not entirely understood, however, the plausible explanation may lie in competitive inhibition of glucose transport via the solute carrier ( SLC ) family of transporters ( specifically " SLCO1B1 " ), important in statin pharmacokinetics.
25.
In other words, if cells can grow despite a high concentration of 3-AT, bait-prey binding must be of high enough stringency to drive reporter gene expression ( HIS3 ) at a sufficient level to overcome the resulting competitive inhibition.
26.
Bovine xanthine oxidase ( from milk ) was originally thought to have a binding site to reduce cytochrome c with, but it has been found that the mechanism to reduce this protein is through XO's superoxide anion byproduct, with competitive inhibition by carbonic anhydrase.
27.
In " in-vitro " experiments THC at extremely high concentrations, which could not be reached with commonly consumed doses, caused competitive inhibition of the AChE enzyme and inhibition of ?-amyloid peptide aggregation, implicated in the development of Alzheimer's disease.
28.
The drug lapatinib ditosylate is classified as S / NM ( a synthetic compound showing competitive inhibition of the natural product ) that is naturally derived or inspired substrate ( Gordon M . Cragg, Paul G . Grothaus, and David J . Newman, Impact of Natural Products on Developing New Anti-Cancer Agents, Chem.
29.
The most potent riboflavin synthase inhibitor is 9-D-ribityl-1, 3, 7-trihydropurine-2, 6, 8-trione, with Ki value of 0.61 ?M . 9-D-ribityl-1, 3, 7-trihydropurine-2, 6, 8-trione is thought to work through competitive inhibition with 6, 7-dimethyl-8-ribityllumazine.
30.
There's a lot sections or sentence need additional footnotes, " Uncompetitive inhibition ", " Non-competitive inhibition ", " Mixed inhibition ", " Uses of inhibitors ", " Control of activity " said there's five main ways that enzyme activity is controlled in the cell, but two sections without any footnotes, consider this article are already been featured for more than 8 years, I think is time to have a good review here .-- talk ) 06 : 50, 13 February 2015 ( UTC)
