| 21. | Perchlorate ions are a competitive inhibitor of the process by which iodide, is actively deposited into thyroid follicular cells.
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| 22. | This selective, competitive inhibitor molecule inhibits the activity of EZH2 and prevents the methylation of histone 3 lysine 27.
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| 23. | However, " de novo " resistance to endocrine therapy undermines the efficacy of using competitive inhibitors like tamoxifen.
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| 24. | However, drugs that are simple competitive inhibitors will have to compete with the high concentrations of ATP in the cell.
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| 25. | It has also been shown that the main active ingredient in cannabis, tetrahydrocannabinol, is a competitive inhibitor of acetylcholinesterase.
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| 26. | It acts as a competitive inhibitor with glucose, such that the enzyme activity is reduced to near-zero while bound.
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| 27. | Certain salts, such as KCl, are known to be competitive inhibitors in respect to 2-phosphoglycerate and mutase activity.
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| 28. | Sinefungin is another SAM-competitive inhibitor similar to DZNep, however, like DZNep, it is not specific to EZH2.
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| 29. | This is demonstrated by the fact that a 2-deoxy analog is an effective competitive inhibitor ( K i = 10mM ).
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| 30. | Methotrexate, a competitive inhibitor of DHFR, is one such anticancer drug that inhibits DHFR . Other drugs include trimethoprim and pyrimethamine.
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