This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases.
22.
In prokaryotes, the term corepressor is used to denote the activating " trp " operon when its corepressor tryptophan is bound to it.
23.
In prokaryotes, the term corepressor is used to denote the activating " trp " operon when its corepressor tryptophan is bound to it.
24.
Only when a corepressor is bound to the lac repressor will the binding site be free for RNA polymerase to carry out transcription of the lac genes.
25.
Mutations of MEF2B enhance its transcriptional activity due to either a disruption with its corepressor CABIN1 or causing the gene to become insensitive to inhibitory signaling events.
26.
In place of the missing H12, Rev-erb? displays a hydrophobic interface that binds the corepressor N-CoR, making it a potent transcriptional repressor.
27.
However, when the ratio of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant breast cancer.
28.
As a part of BCL6 corepressor complex, MTA3 regulates BCL6-dependent repression of target genes, including PRDM1, and modulates the differentiation of B-cells.
29.
This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT . Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.
30.
The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including splice variants encoding different isoforms have been characterized.
