Because chemoresponsive nerve fibers are present in all types of skin, chemesthetic sensations can be aroused from anywhere on the body's surface as well as from mucosal surfaces in the nose, mouth, eyes, etc . Mucus membranes are generally more sensitive to chemesthetic stimuli because they lack the barrier function of cornified skin.
22.
EOS is an intermediate component in a proposed multi-step metabolic pathway which delivers VLCFAs to the cornified lipid envelop in the skin's Stratum corneum; the presence of these wax-like, hydrophobic VLCFAs is needed to maintain the skin's integrity and functionality as a water barrier ( see Lung microbiome # Role of the epithelial barrier ).
23.
This process is particularly important in the terminal differentiation of the epidermis, where TGs heavily cross-link keratins and a range of differentiation-specific structural proteins, such as involucrin, loricrin, filaggrin, and small proline-rich proteins, in the formation of the cornified cell envelope in the biogenesis of the stratum corneum, the outermost, dead layer of the epidermis ( Kalinin et al . 2002 ).
24.
Three genes in the " PSORS1 " locus have a strong association with psoriasis vulgaris : " HLA-C " variant " HLA-Cw6 ", which encodes a MHC class I protein; " CCHCR1 ", variant WWC, which encodes a coiled protein that is overexpressed in psoriatic epidermis; and " CDSN ", variant allele 5, which encodes corneodesmosin, a protein which is expressed in the granular and cornified layers of the epidermis and upregulated in psoriasis.
