One is the dentate gyrus of the hippocampus, and there is evidence that the newly created neurons play a role in storing new memories.
22.
In 2015, Losonczy and his PhD student Nathan Danielson discovered the role of neurogenesis in the dentate gyrus in memory formation and pattern separation.
23.
Some references include the dentate gyrus and the subiculum in the hippocampal formation, and others also include the presubiculum, parasubiculum, and entorhinal cortex.
24.
These experiments were carried out by stimulating presynaptic fibers of the perforant pathway and recording responses from a collection of postsynaptic cells of the dentate gyrus.
25.
Hippocampal lesioning led to a considerable loss of cells in pyramidal cells ( CA1-CA3 ) as well as granule cells in the dentate gyrus.
26.
Age-related memory loss is believed to originate in the dentate gyrus, whereas Alzheimer's is believed to originate in the entorhinal cortex.
27.
This was determined by examining the effects of applying an electric stimulus to the hippocampal dentate gyrus ( DG ) in normal and GADD45b knockout mice.
28.
Many of the newborn dentate gyrus neurons die shortly after they are born, but a number of them become functionally integrated into the surrounding brain tissue.
29.
As expected, a single pulse of electrical stimulation to fibers of the perforant pathway caused excitatory postsynaptic potentials ( EPSPs ) in cells of the dentate gyrus.
30.
In humans and other mammals, a cross-section of the hippocampus shows the dentate gyrus as well as the dense cell layers of the CA fields.
