In patients with mutations in SCN4A or CACNA1S, therefore, the channel has a reduced excitability and signals from the central nervous system are unable to depolarise the muscle.
22.
Action potentials from the central nervous system cause end-plate potentials at the NMJ which causes sodium ions to enter by Na v 1.4 and depolarise the muscle cells.
23.
Alternative definition : ED95 ( when referring to non depolarising muscle relaxants ) is the ED50 from a cumulative log dose response curve where the quantum is a 95 % reduction in twitch height
24.
This causes the cell to depolarise, and creates an action potential that is transmitted along the spiral ganglion, which sends information through the auditory portion of the vestibulocochlear nerve to the temporal lobe of the brain.
25.
Polarised illumination, coupled with a cross-polarised viewer, reduces ( polarised ) skin surface reflection, thus allowing visualisation of skin structures ( the light from which is depolarised ) without using an immersion fluid.
26.
These cells generate action potentials that propagate down axons to the nerve endings in the pituitary; the endings contain large numbers of oxytocin-containing vesicles, which are released by exocytosis when the nerve terminals are depolarised.
27.
"' Hexamethonium "'is a non-depolarising ganglionic blocker, a nicotinic antagonist that acts in autonomic ganglia by binding mostly in or on the N N receptor, and not the acetylcholine binding site itself.
28.
As a consequence, Europe's integration deepened, the continent became depolarised, and the European Union expanded to subsequently include many of the formerly communist European countries Romania and Bulgaria ( 2007 ) and Croatia ( 2013 ).
29.
Defibrillation is the definitive treatment of ventricular fibrillation, whereby an electrical current is applied to the ventricular mass either directly or externally through pads or paddles, with the aim of depolarising enough of the myocardium for co-ordinated contractions to occur again.
30.
Observations " in vitro " and of tumours extracted from those 5 patients suggest that DCA might act against cancer cells by depolarising abnormal mitochondria found in glioblastoma cancer cells allowing the mitochondria to induce apoptosis ( cell death ) of the malignant cells.
