Changing dose ranges tend to result in varying phenotypes and timing of exposure, gender, and gender predisposition introduce even more levels of complexity in how these substances effect the human body.
22.
Rivaroxaban has predictable pharmacokinetics across a wide spectrum of patients ( age, gender, weight, race ) and has a flat dose response across an eightfold dose range ( 5 40 mg ).
23.
Some newer drugs, like cholesterol lowering agents and a nose spray for allergies, come with labeling that gives a recommended dose range and advises doctors to try to find the lowest effective dose.
24.
An "'ago-allosteric modulator "'acts as an agonist and an enhancer for endogenous agonists in increasing agonist potency ( the dose range over which a response is produced ) and providing " superagonism ".
25.
It has neuroprotective effects particularly in lengthening the QTc interval, which could potentially lead to heart failure, and so this meant that subsequent trials were limited to using only the low dose range.
26.
The most potent isomer was EA-2233-2, with an active dose range in humans of 0.5 2.8 ?g / kg ( i . e . ~ 35 200 ?g for a 70 kg adult ).
27.
Therefore, a person using a typical oral ingestible product that provides 0.25 mg CPC per dose will need to take 4000 doses at one time before they would be in the estimated fatal dose range.
28.
Many drivers have blood levels far exceeding the therapeutic dose range and often in combination with other alcohol, illegal, or prescription drugs of abuse, suggesting a high degree of abuse potential for benzodiazepines, zolpidem, and zopiclone.
29.
In animal studies, MCOPPB produces potent anxiolytic effects, with no inhibition of memory or motor function, and only slight sedative side effects which do not appear until much higher doses than the effective anxiolytic dose range.
30.
Using atropine as an antidote to nerve agents requires an initial dose ranging from 2 mg to 4 mg, then 2 mg repeated every five or 10 minutes until the symptoms disappear, a council diplomat said.
