| 21. | These intramolecular interactions are relevant to the distribution of products in the Hofmann elimination reaction, which converts amines to alkenes.
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| 22. | In the elimination reaction, all five participating reaction centers are coplanar and, therefore, the reaction stereochemistry is syn.
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| 23. | The enzyme's cleavage of the argininosuccinate, to form fumarate and arginine, occurs through an E1cb elimination reaction.
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| 24. | If occurring in consecutive steps, the intermediate is identical to that which would be generated from an E1cb elimination reaction.
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| 25. | It is therefore called addition-elimination reaction and may occur in carboxylic acid derivatives such as chlorides, esters or anhydrides.
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| 26. | For instance in the E1cB elimination reaction and in organometallic chemistry in for instance a Grignard reaction or in alkyl lithium chemistry.
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| 27. | The rule makes no generalizations about the stereochemistry of the newly formed alkene, but only the regiochemistry of the elimination reaction.
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| 28. | Bredt's rule can be useful for predicting which isomer is obtained from an elimination reaction in a bridged ring system.
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| 29. | Addition of alkali to the ?-substituted compound on the other hand leads to an elimination reaction with liberation of ethylene.
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| 30. | In a subsequent step an elimination reaction liberates HX ( for instance hydrochloric acid ) and an aryl vinyl compound is formed.
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