The contribution of Epo and EpoR to neuroprotection and development are not as clearly understood as its role in erythropoiesis in hematopoietic tissue.
22.
The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.
23.
Lack of either causes maturation failure in the process of erythropoiesis, which manifests clinically as reticulocytopenia, an abnormally low amount of reticulocytes.
24.
However, KLF2 and EKLF have been found to interact in embryonic erythropoiesis . ?-globin and ?-globin in embryonic proerythroblasts.
25.
Erythropoiesis impairment begins when the serum iron level falls to less than 50 ?g / dL and transferrin saturation is less than 16 %.
26.
Recent studies have also shown that the peptide hormone hepcidin may play a role in the regulation of hemoglobin production, and thus affect erythropoiesis.
27.
Erythroferrone, produced in erythroblasts, has been identified as inhibiting hepcidin and so providing more iron for hemoglobin synthesis in situations such as stress erythropoiesis.
28.
These mice exhibit elevated erythropoiesis consistent with the idea that phosphatase recruitment ( and therefore the shutting down of signaling ) is aberrant in these mice.
29.
KLF2 is now believed to play an important role in embryonic erythropoiesis, specifically in regulating embryonic and adult ?-globin gene expression was unaffected.
30.
Clinical research studies where the NHP was utilized include investigations into erythropoiesis-stimulating agents, glucocorticoid replacement therapy and transcutaneous electrical nerve stimulation for tinnitus.
