In addition to its activation, ALOX5 must gain access to its polyunsaturated fatty acid ( PUFA ) substrates, which commonly are bound in an ester linkage to the " sn " 2 position of membrane phospholipids ( see phospholipid ), in order to form biologically active products.
22.
Furthermore, balanol is sometimes referred to as ophiocordin, an antifungal agent produced by the fungus " Cordyceps ophioglossoides " whose structure is regioisometric to that of balanol; that is, in ophiocordin, the benzophenone is linked to the hexahydroazepane instead via an amide; the 4-hydroxy benzoyl group and hexahydroazepane are connected with an ester linkage.
