ACAT also plays an important role in foam cell formation and atherosclerosis by participating in accumulating cholesterol esters in macrophages and vascular tissue.
22.
In Germany he became the first to describe the cholesterinesterphagozyten, which derive from macrophages and today are known as foam cells.
23.
Foam cells are not dangerous as such, but can become a problem when they accumulate at particular foci thus creating a necrotic centre of atherosclerosis.
24.
Lee et al . found that infecting mice with " T . forsythia " induced foam cell formation and accelerated the formation of atherosclerotic lesions.
25.
Foam cells are very small in size and can only be truly detected by examining a fatty plaque under a microscope after it is removed from the body.
26.
When foam cells die, their contents are released, which attracts more macrophages and creates an extracellular lipid core near the center to inner surface of each atherosclerotic plaque.
27.
In addition to this possible mechanism of foam cell generation, an increase in the levels of chemically modified LDL particles may also lead to an increase in endothelial damage.
28.
The foam cells of monocyte / macrophage origin are positive for KP1, HAM56, CD11b and CD68 as pointed out by Nakashiro et al . in xanthogranulomatous cholecystitis ).
29.
The foam cells and platelets encourage the migration and proliferation of smooth muscle cells, which in turn ingest lipids, become replaced by collagen and transform into foam cells themselves.
30.
The foam cells and platelets encourage the migration and proliferation of smooth muscle cells, which in turn ingest lipids, become replaced by collagen and transform into foam cells themselves.
