In prostate cancer a frameshift mutation changes the open reading frame ( ORF ) and prevents apoptosis from occurring.
22.
During testing of coding regions to identify mutations, 116 genetic variants were discovered, including 61 frameshift mutations.
23.
It may be interesting to touch on how frameshift mutation rates can vary based on positioning within the genome.
24.
A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids.
25.
The frameshift mutations lead to an early stop codon which is known to play a role in the disease in infants.
26.
The effects of neighboring bases and secondary structure to detect the frequency of frameshift mutations has been investigated in depth using fluorescence.
27.
This could use disablement detection, which looks for nonsense or frameshift mutations that would truncate or collapse an otherwise functional coding sequence.
28.
Reverse transcriptase, as opposed to RNA Polymerase II, is thought to be a stronger cause of the occurrence of frameshift mutations.
29.
Experiments can be run to determine the frequency of the frameshift mutation by adding or removing a pre-set number of nucleotides.
30.
The other three are missense mutations and frameshift mutations, which lead to a shortening of amino acid sequence in the C terminus.
