If well chosen, these functional clusters contain a significantly higher density of genetic interactions than other regions of the genome and thus allows for a higher rate of detection while dramatically decreasing the number of gene pairs to be examined.
22.
Protein-protein relationships are often the result of multiple types of interactions or are deduced from different approaches, including co-localization, direct interaction, suppressive genetic interaction, additive genetic interaction, physical association, and other associations.
23.
Protein-protein relationships are often the result of multiple types of interactions or are deduced from different approaches, including co-localization, direct interaction, suppressive genetic interaction, additive genetic interaction, physical association, and other associations.
24.
Japanese wolves likely underwent a process of island dwarfism 7, 000 13, 000 years ago in response to these climatological and ecological pressures . " C . l . hodophilax ", as it inhabited higher elevations and had access to larger prey, as well as a continuing genetic interaction with dispersing wolves from Siberia.
25.
The latest study regarding Turkish genetics from 2014-has utilized the whole genome sequencing of Turkish individuals . Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa The study led by Can Alkan of University of Washington, Seattle has been published in the journal BMC genomics.
26.
High-throughput methods of analyzing these types of interactions have been useful in expanding our knowledge of genetic interactions . " Synthetic genetic arrays " ( SGA ), " diploid based synthetic lethality analysis on microarrays " ( dSLAM ), and " epistatic miniarray profiles " ( E-MAP ) are three important methods which have been developed for the systematic analysis and mapping of genetic interactions.
27.
High-throughput methods of analyzing these types of interactions have been useful in expanding our knowledge of genetic interactions . " Synthetic genetic arrays " ( SGA ), " diploid based synthetic lethality analysis on microarrays " ( dSLAM ), and " epistatic miniarray profiles " ( E-MAP ) are three important methods which have been developed for the systematic analysis and mapping of genetic interactions.
28.
His Ph . D . advisor at MIT was David Botstein, and the title of his thesis was " Genetic analysis of the yeast microtubule cytoskeleton . " Stearns'thesis work was notable for identifying exceptions to the genetic complementation test that were useful for defining genetic interactions, and for the first use of the term " synthetic lethality " in the modern sense of two non-lethal mutations resulting in lethality in the double mutant.
29.
During this time, he worked on developing an approach, termed E-MAP, for high throughput generation and quantitative analysis of genetic interaction data . ( REF ) Combining the genetic and protein-protein interaction data led to a deeper understanding of the relationship between physical and genetic data ( REF ) as well as insight into a wide variety of biological processes, including chromatin function, transcription, protein trafficking and RNA processing ( REFs ).
30.
The Bull games or " Taurokathapsia " ( Bull-leaping ), a form of gymnastics performed by young acrobats and bulls in ancient Crete, are quite well-known; reading Ctesias'report, one wonders if dogs were ever included, or used to control any bull that became too aggressive during the games or the training sessions . ( This passage also underlines the co-existence and inevitable genetic interaction between Cretan populations of Alopekis and Cretan Hounds.
