Lusher and colleagues reported on the peculiar side effect profile ( i . e ., anaphylaxis, nephrotic syndrome ) of recombinant factor IX in patients with hemophilia B.
22.
Meanwhile, in St . Petersburg, Alexei is confined to his bed suffering from severe bruising to his leg caused by Hemophilia B, a disease that prevents proper blood clotting.
23.
Defective calcium binding to coagulation factor IX contributes to the development of hemophilia B . Individuals afflicted with this hereditary disease tend to develop hemorrhages, potentially leading to life-threatening conditions.
24.
Monday's news comes on the heels of even more encouraging results from a gene therapy trial for hemophilia B, the less common form which affects 1 in 50, 000 men.
25.
About 5, 000 Americans suffer from hemophilia B . They produce insufficient levels of a clotting protein known as Factor IX . As a result, blood leaks into their joints.
26.
Bayer AG's American subsidiary signed a deal Friday with the U . S . biotechnology firm Avigen for worldwide rights to distribute its gene therapy treatment for hemophilia B, Coagulin-B.
27.
In the hemophilia B trial the vector carries the correct version of the human gene for Factor IX, one of the cascade of proteins involved in making the blood clot.
28.
Cohen said protein injections to curb hemophilia A represent a market of $ 1 . 6 billion in the United States, more than four times the market for hemophilia B.
29.
A gene therapy treatment for hemophilia B might be of great benefit, he said, and would need to be weighed against the risks, including that of inadvertently modifying the human germline.
30.
Deficiency of this protein causes hemophilia B . It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia.
