| 21. | The core of the histones H2A and H2B can also be modified.
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| 22. | Often, DNA methylation and histone deacetylation work together in gene silencing.
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| 23. | Also, activation or localization of two histone acetyltransferases can be oncogenic.
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| 24. | The reverse reaction of the acetylation is catalyzed by histone deacetylase 6.
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| 25. | Deacetylation of histones stabilizes tightly coiled nucleosomes, inhibiting RNA polymerase access.
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| 26. | Histone acetylation plays an important role in the regulation of gene expression.
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| 27. | Transcription is also repressed by histone deacetylase-independent means.
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| 28. | Histone H2B is a lightweight structural protein made of 126 amino acids.
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| 29. | Histone H2B s amino acid sequence is highly evolutionarily conserved.
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| 30. | This can be done by modifying histones at certain sites by methylation.
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