The mechanism for ventricular arrhythmogenesis was demonstrated to be indirect, and associated with autoimmune attack of the adrenal gland and secondary hyperaldosteronism ( KCNE3 is not detectable in the adrenal gland ).
22.
Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism ( including Conn's syndrome ) and female hirsutism ( due to additional antiandrogen actions ).
23.
Instead, experiments isolating the perfusion pressures seen by glomerular capillaries from heightened systemic pressures due to hyperaldosteronism have shown that Na + excretion remains minimal until the kidney is exposed to heightened perfusion pressures.
24.
It also mimics hyperaldosteronism, which is an adrenal gland disorder, so an endocrinologist might be able to help with the initial diagnosis . talk ) 15 : 12, 5 January 2009 ( UTC)
25.
If there is a primary hyperaldosteronism, the decreased renin ( and subsequent decreased angiotensin II ) will not lead to a decrease in aldosterone levels ( a very helpful clinical tool in diagnosis of primary hyperaldosteronism ).
26.
If there is a primary hyperaldosteronism, the decreased renin ( and subsequent decreased angiotensin II ) will not lead to a decrease in aldosterone levels ( a very helpful clinical tool in diagnosis of primary hyperaldosteronism ).
27.
When hydrostatic pressures are raised in the peritubular capillaries such as seen in hyperaldosteronism, Starling forces begin to favor " backflow " of Na + and water from the interstitium into the tubules thus, increasing Na + excretion.
28.
If primary hyperaldosteronism is confirmed biochemically, CT scanning or other cross-sectional imaging can confirm the presence of an adrenal abnormality, possibly an adrenal cortical adenoma ( aldosteronoma ), adrenal carcinoma, bilateral adrenal hyperplasia, or other less common changes.
29.
When the iodine atom is a radioactive isotope ( iodine-125 or iodine-131 ), it is used as an adrenal cortex radiocontrast agent for in the assessment of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma and adrenal remnants following total adrenalectomy.
30.
Yet another related disorder causing hypertension is glucocorticoid remediable aldosteronism, which is an autosomal dominant disorder in which the increase in aldosterone secretion produced by ACTH is no longer transient, causing of primary hyperaldosteronism, the Gene mutated will result in an aldosterone synthase that is ACTH-sensitive, which is normally not . monogenic form of human hypertension.
