The ACADS gene has also been implicated in delaying the onset of Prader-Willi Syndrome, which is characterized by hypotonia, growth failure, and neurodevelopmental delays in the first years of life, and hyperphagia and obesity much later.
22.
Unlike most other snoRNAs, SNORD116 is expressed prevalently in the brain ( but is absent in PWS patients ) and lacks any significant complementarity with ribosomal RNA . Mouse models of PWS show similar symptoms to humans ( hyperphagia and growth deficiency ), providing further evidence that PWS is directly linked to the deletion of SNORD116.
23.
In addition, there are certain features that have been shown to increase the chances that depressed patients are suffering from a bipolar disorder including atypical symptoms of depression like hypersomnia and hyperphagia, a family history of bipolar disorder, medication-induced hypomania, recurrent or psychotic depression, antidepressant refractory depression, and early or postpartum depression.
24.
"Zugunruhe " has been artificially induced in experiments by simulating long days . Some studies on White-crowned Sparrows have suggested that prolactin is involved in the pre-migratory hyperphagia ( feeding ), fattening and " Zugunruhe " however others have found that prolactin may merely be associated with lipogenesis ( fat accumulation ).
