A "'gonadotropin-releasing hormone agonist "'( "'GnRH agonist "', "'GnRH A "') is a synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones LH . However, after the initial " flare " response, continued stimulation with GnRH agonists desensitizes the pituitary gland ( by causing GnRH receptor downregulation ) to GnRH . Pituitary desensitization reduces the secretion of LH and FSH and thus induces a state of hypogonadotropic hypogonadal anovulation, sometimes referred to as pseudomenopause or medical oophorectomy .
