| 21. | Because of a high immunogenicity of polyclonal antibodies, almost all patients have an acute reaction to the treatment.
|
| 22. | There are also several models which are helpful in understanding the nature of specificity in immune network and immunogenicity.
|
| 23. | As of 2009 the manufacturer was conducting a trial to compare the immunogenicity and safety of Cervarix with Gardasil.
|
| 24. | Secondary objectives are response rate, duration of response, overall survival, safety, immunogenicity, and pharmacokinetics.
|
| 25. | Generic versions of biologic drugs, or biosimilars, require clinical trials for immunogenicity in addition to tests establishing bioequivalency.
|
| 26. | Deimmunized protein therapeutics are now entering the clinic; initial results appear to support this approach to reducing immunogenicity risk.
|
| 27. | GeoVax published results of Phase 1 safety and immunogenicity testing for its preventative vaccine trial on March 1, 2011.
|
| 28. | This technology has not received approval for clinical trial because of the high immunogenicity of cells loaded in the capsules.
|
| 29. | AAV also presents very low immunogenicity, mainly restricted to generating neutralizing antibodies, and little well defined cytotoxic response.
|
| 30. | Since the impact of immunogenicity can be quite severe, regulatory agencies are developing risk-based guidelines for immunogenicity screening.
|
