"' Original antigenic sin "', also known as the "'Hoskins effect "', refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign entity ( e . g . a virus or bacterium ) is encountered.
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Immunological memory : While the property of memory in the adaptive system had been known for decades, it was Lanzavecchia s laboratory that described in humans a fundamental division of memory T cells into two major subtypes, central memory and effector memory T cells, which play distinct roles in secondary immune responses ( 11 ).
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In addition to this mechanism for immunological memory, there is now pretty good evidence that the innate immune system has some capacity for " memory " in up-regulating innate immune components ( e . g . natural killer cells, complement system ) at heavily-exposed sites of the body, perhaps making people somewhat more resistant to certain exposures.
