"' AMB-CHMINACA "'( also known as "'MA-CHMINACA "') is an indazole-based synthetic cannabinoid that is a potent agonist of the CB 1 receptor and has been sold online as a designer drug.
22.
"' FUB-APINACA "'( also known as "'FUB-AKB48 "') is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB 1 receptor and has been sold online as a designer drug.
23.
"' MDMB-CHMINACA "'( also known as "'MDMB ( N )-CHM "') is an indazole-based synthetic cannabinoid that acts as a potent agonist of the CB 1 receptor and has been sold online as a designer drug.
24.
Structurally it closely resembles cannabinoid compounds from patent WO 2003 / 035005 but with a 5-fluoropentyl chain on the indazole 1-position, and 5F-APINACA falls within the claims of this patent, as despite not being disclosed as an example, it is very similar to the corresponding pentanenitrile and 4-chlorobutyl compounds which are claimed as examples 3 and 4.
25.
"' 5F-CUMYL-PINACA "'( also known as "'SGT-25 "'and sometimes sold in e-cigarette form as "'C-Liquid "') is an indazole-3-carboxamide based synthetic cannabinoid . 5F-CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with approximately 4x selectivity for CB 2 receptors.
26.
It is the indole core analogue of 5F-AMB . Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group with attached isopropyl or t-butyl substituent, have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to a large number of deaths in Russia, Japan, Europe and the United States.
27.
It had never previously been reported in the scientific or patent literature, and was first identified by laboratories in Japan in March 2012 as an ingredient in synthetic cannabis smoking blends, along with a related compound APICA . Structurally it closely resembles cannabinoid compounds from patent WO 2003 / 035005 but with a simple pentyl chain on the indazole 1-position, and AKB48 falls within the claims of this patent despite not being disclosed as an example.
28.
There is currently a new drug under development for glaucoma; " Peripherally selective 5-HT2A agonists such as the indazole derivative AL-34662 are currently under development and show significant promise in the treatment of glaucoma . " and from http : / / en . wikipedia . org / wiki / 5-HT2A _ receptor " 5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus ."
29.
"' 5F-ADB "'( also known as "'5F-MDMB-PINACA "') is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products . 5F-ADB is a potent agonist of the CB 1 receptor, though it is unclear whether it is selective for this target . 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance.
30.
"' 5F-ADB "'( also known as "'5F-MDMB-PINACA "') is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products . 5F-ADB is a potent agonist of the CB 1 receptor, though it is unclear whether it is selective for this target . 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance.
