In the opposite case, juxtaglomerular cells are stimulated to release more renin, which stimulates the renin-angiotensin system, producing angiotensin I which is converted by Angio-Tensin Converting Enzyme ( ACE ) to angiotensin II . Angiotensin II then causes preferential constriction of the efferent arteriole of the glomerulus and increases the GFR.
22.
Renin cleaves the peptide bond between the leucine ( Leu ) and valine ( Val ) residues on angiotensinogen, creating the ten-amino acid peptide ( des-Asp ) angiotensin I . Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure ( < 90mmHg systolic blood pressure ) at the juxtaglomerular cells, or decreased delivery of Na + and Cl-to the macula densa.
