| 21. | In addition, patients usually show severe hyperventillation due to profound metabolic acidosis mostly related to lactic acidosis.
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| 22. | This mutation is associated with both CPEO and Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes ( MELAS ).
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| 23. | A second case with failure to thrive, developmental delay, lactic acidosis and severe encephalopathy was reported in 2014.
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| 24. | Resolution of lactic acidosis is observed in patients with E1 alpha enzyme subunit mutations that reduce enzyme stability.
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| 25. | Most people with MELAS have a buildup of lactic acid in their bodies, a condition called lactic acidosis.
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| 26. | In rare cases, Glucovance may cause lactic acidosis, which can be fatal in up to half of the cases.
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| 27. | Lactic acidosis, a potentially life-threatening buildup of lactic acid in the body, may also occur due to mitochondrial toxicity.
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| 28. | The excess hydrogen cations produced during lactic acidosis are widely believed to actually derive from production of lactic acid.
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| 29. | Females with residual pyruvate dehydrogenase activity will have no uncontrollable systemic lactic acidosis and few, if any, neurological symptoms.
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| 30. | It is expected that most cases will be of mild severity and have a clinical presentation involving lactic acidosis.
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