| 21. | Ligase ribozymes may have been part of such a pre-biotic RNA world.
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| 22. | Activation and recruitment of DNA Ligase I seem to be associated with posttranslational modifications.
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| 23. | This interaction is crucial for the recruitment of substrates to the ubiquitin ligase complex.
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| 24. | Most obviously, for example, formate-tetrahydrofolate ligase synthesizes 10-formyltetrahydrofolate.
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| 25. | DTX1 function as ubiquitin ligase protein by facilitating ubiquitination and allowing degradation of MEKK1.
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| 26. | Ligase works to fill these nicks in, thus completing the newly replicated DNA molecule.
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| 27. | DNA ligase then joins the deoxyribonucleotides together, completing the synthesis of the lagging strand.
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| 28. | Once paired, the phosphodiester bonds of the fragments can be joined by DNA ligase.
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| 29. | Additionally, E3 SUMO-protein ligase PIAS is an alternative name for PIAS proteins.
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| 30. | However, it is not needed for E3 SUMO-protein ligase activity to occur.
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