However, a rare abnormality of AMN can also cause vitamin B12 anemia; this condition is referred to as " Imerslund-Gr�sbeck syndrome ( IGS ) . " Autosomal recessive mutations in both component of Cubam ( AMN, and cubilin ) is responsible for Imerslund-Gr�sbeck syndrome, which manifests as macrocytic, megaloblastic anemia.
22.
*Deoxyadenosyl B 12 or as it is sometimes referred to Ado B 12 : Ado B 12 is essential for acid-base maintenance of the blood, simply because Ado B 12 is the catalyst that assists the conversion of, Methylmalonyl CoA, into Succinyl CoA . In absence of vitamin B 12, levels of Methylmalonyl CoA increase, and this is in fact a great way to distinguish folate deficiency macrocytic anemia, from vitamin B 12 anemia.
