In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells ( cells that produce bone marrow cell transplants are necessary . ( In autologous BMTs, cells are removed from the patient before the treatment, multiplied and then re-injected afterward; in " allogenic"
22.
There have been scattered reports of various problems when the oral form is used, including problems caused by myelosuppression ( leukopenia, neutropenia, agranulocytosis, aplastic anaemia, and thrombocytopenia, as well as hair loss, peripheral neuropathy, pancreatitis, liver problems, myocarditis and pericarditis, allergic and fibrotic lung reactions, lupus erythematosus-like reactions and rash ( including urticaria ), drug fever, interstitial nephritis and nephrotic syndrome, usually reversible on withdrawal.
