Since the introduction of nalidixic acid in 1962, more than 10, 000 analogs have been synthesized, but only a handful have found their way into clinical practice.
22.
Nalidixic acid is thus considered to be the predecessor of all members of the quinolone family, including the second, third and fourth generations commonly known as fluoroquinolones.
23.
When used in conjunction with nalidixic acid ( which destroys gram-negative bacteria ), it can be used to isolate the streptococci bacteria for the diagnosis of an infection.
24.
They do not grow on CNA ( colistin nalidixic acid ) agar because, although they are resistant to colistin, they are susceptible to quinolones such as nalidixic acid.
25.
They do not grow on CNA ( colistin nalidixic acid ) agar because, although they are resistant to colistin, they are susceptible to quinolones such as nalidixic acid.
26.
Low levels of penicillin and nalidixic acid are also present in LJ medium to inhibit growth of Gram-positive and Gram-negative bacteria, to limit growth to " Mycobacterium " species only.
27.
One reason that shigella dysentery presents such a danger is that the bacterium that causes it, S . dysenteriae type 1, has become largely resistant to antibiotics, including Negram, whose generic name is nalidixic acid.
28.
To increase recovery of GBS, swabs can also be inoculated previously into a selective enrichment broth medium, such as the Todd-Hewitt broth supplemented with gentamicin or colistin and nalidixic acid and incubated for 18 24 hours at 35-37 �C.
29.
These were mitomycin C ( which introduces DNA inter-strand crosslinks ), norfloxacin, ofloxacin, and nalidixic acid ( inhibitors of DNA gyrase that cause double-strand breaks ), bicyclomycin ( causes double-strand breaks ) and hydroxyurea ( causes oxidation of DNA bases ).
30.
These molecules were norfloxacin, ofloxacin and nalidixic acid ( inhibitors of DNA gyrase that produce double strand breaks ), mitomycin C ( which produces inter-strand cross-links ), bicyclomycin ( causes single-and double-strand breaks ), and hydroxyurea ( causes oxidation of DNA bases ).
