"' GD2 "'is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans.
22.
"' Dinutuximab "'( tradename Unituxin ) is a monoclonal antibody that targets glycolipid GD2, expressed on neuroblastoma cells and on normal cells of neuroectodermal origin, including the central nervous system and peripheral nerves.
23.
The syndrome involves defects in the nervous, auditory, skeletal, visual, and endocrine systems and encompasses numerous symptoms, bearing striking similarity to other known syndromes of neuroectodermal nature such as : Werner syndrome, Cockayne syndrome and Refsum syndrome.
24.
It is linked that RAB7a levels and function were independent of melanocyte lineage-specific transcription factors ( MITF ) but recent research has shown that SOX10 ( a neuroectodermal master modulator ) and MYC ( an oncogene ) are the major regulators.
25.
Racotumomab triggers an immune response against the tumor antigen N-glycolil ( NGc ) GM3 ( NGcGM3 ), a type of ganglioside present on the cell surface of malignant cells from lung and breast, melanoma, as well as neuroectodermal pediatric tumors.
26.
Malignant ectomesenchymoma ( MEM ) is a rare tumor of soft tissues or the CNS, which is composed of both neuroectodermal elements [ represented by ganglion cells and / or well-differentiated or poorly differentiated neuroblastic cells such as ganglioneuroma, ganglioneuroblastoma, neuroblastoma, peripheral primitive neuroectodermal tumors PNET ] and one or more mesenchymal neoplastic elements, usually rhabdomyosarcoma.
27.
Malignant ectomesenchymoma ( MEM ) is a rare tumor of soft tissues or the CNS, which is composed of both neuroectodermal elements [ represented by ganglion cells and / or well-differentiated or poorly differentiated neuroblastic cells such as ganglioneuroma, ganglioneuroblastoma, neuroblastoma, peripheral primitive neuroectodermal tumors PNET ] and one or more mesenchymal neoplastic elements, usually rhabdomyosarcoma.
