Neurofilament accumulation in axons has been observed in sporadic cases of ALS as well as in SOD1 patients, possibly interfering with axonal transport, leading to cell death from SOD1 toxicity.
22.
Dr . Jean-Pierre Julien and his colleagues at the Montreal General Hospital Research Institute in Canada found that they could reproduce ALS in mice by giving them an abnormal neurofilament gene.
23.
An example of the application of this technique in neuroscience is the immunolabeling of antigens like NGF-Inducible Large External glycoprotein ( NILE-GF ), choline acetyltransferase, parvalbumin, and neurofilament protein.
24.
With immunohistochemistry, the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron specific enolase, serotonin, neurofilament and Neural cell adhesion molecule; they are S-100 protein negative.
25.
Neuron-specific enolase ( NSE ) positive, NSE negative, synaptophysin negative, neurofilament negative, TUJ1 positive, and nestin positive have been expressed in astroblastoma cell populations, showing significant promise in neuronal stem cell treatment for the tumor.
26.
During a clinical trial for one of the main MS drugs, a catheter was inserted into the brain's neurofilament light chain ( NF-L ) level, in CSF and serum, is a sensitive and specific marker for white matter axonal injury
27.
In the adult mammal neurofilament subunit proteins coassemble " in vivo ", forming a heteropolymer that contain NF-L or alpha-internexin plus NF-M or NF-H . Peripherin and vimentin may incorporate into neurofilaments along with these proteins.
28.
Gigaxonin is a member of the cytoskeletal kelch ( Broad-Complex, Tramtrack and Bric a brac ) repeat family . ( Kelch repeats are predicted to form a beta-propeller shape . ) Gigaxonin plays a role in neurofilament architecture and is mutated in giant axonal neuropathy.
29.
As development continues into neurons the neurofilament triplet proteins ( NF-L : neurofilament low molecular mass, NF-M : neurofilament medium molecular mass, and NF-H : neurofilament high molecular mass ) are expressed in increasing molecular mass order as ?-internexin expression decreases.
30.
As development continues into neurons the neurofilament triplet proteins ( NF-L : neurofilament low molecular mass, NF-M : neurofilament medium molecular mass, and NF-H : neurofilament high molecular mass ) are expressed in increasing molecular mass order as ?-internexin expression decreases.
