Chaplin, a director of the USDA Research Laboratory at Oxford, North Carolina, had described the need for a higher nicotine tobacco plant in the trade publication " World Tobacco " in 1977, and had bred a number of high-nicotine strains based on a hybrid of " Nicotiana tabacum " and " Nicotiana rustica ", but they were weak and would blow over in a strong wind.
22.
These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein; vertebrate YAP protein, substrate of LATS1 and LATS2 serine-theronine kinases of the Hippo tumor suppressor pathway; " Mus musculus " ( Mouse ) NEDD4, involved in the embryonic development and differentiation of the central nervous system; " Saccharomyces cerevisiae " ( Baker's yeast ) RSP5, similar to NEDD4 in its molecular organization; " Rattus norvegicus " ( Rat ) FE65, a transcription-factor activator expressed preferentially in brain; " Nicotiana tabacum " ( Common tobacco ) DB10 protein, amongst others.
