| 21. | Another deviation from the regular Hammet equation is explained by the charge of nucleophile.
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| 22. | The polarizability of the nucleophile or involvement of intramolecular catalysis also plays a role.
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| 23. | The rate of reaction of nucleophile and electrophile depends on the identity of both.
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| 24. | It is a nucleophile and a strong base.
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| 25. | Instead, Glu-537 is the actual nucleophile, binding to a galactosyl intermediate.
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| 26. | S N 2 occurs where the central carbon atom is easily accessible to the nucleophile.
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| 27. | This enolate cyclizes to a cyclopropanone intermediate which is then attacked by the hydroxide nucleophile.
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| 28. | The nucleophile approaches the carbon of the carbonyl group at the Burgi-Dunitz angle.
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| 29. | Subsequently, the functional role of the SOH center as nucleophile has obtained experimental support.
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| 30. | E n is the term Edwards introduced to account for the polarizability of the nucleophile.
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